Appendix removal is linked to lower risk of Parkinson’s

Parkinson's-inducing protein in the gut points to possible link between gastrointestinal tract and disease

Researchers looked at a half million people in Sweden and found those whose appendix had been removed early in life were at an nearly a 20-percent lower risk of developing Parkinson's compared to those who still had their appendix.

This is amounts to a 16.9% decrease in the odds of acquiring the disease-but in absolutes, that's the difference between an 0.14 per cent chance of acquiring the disease for those who hadn't gotten their appendix removed versus an 0.11 per cent chance for those who had. The research "further supports the notion that [Parkinson's] starts in the gut", Dr. Ted Dawson, a professor of neurodegenerative diseases at Johns Hopkins University who was not part of the study, told Live Science.

Having an appendectomy would appear to have the unexpected advantage of reducing the risk of Parkinson's disease by as much as 25% according to a study from the Van Andel Research Institute. And made the notice published in the American medical journal "Science Translational Medicine", confirmed that the gut and the immune system plays a role in triggering Parkinson's disease.

The research team, based at the Van Andel Research Institute (VARI) in the U.S., have suggested a link between the removal of the appendix and a reduced risk of developing Parkinson's.


It is the first time that scientists associate Parkinson to the instrument body, which appears to act as a "reservoir" for abnormal neuronal proteins (alpha-synuclein) associated with the onset and exacerbation of disease.

The appendix has a reputation for being unnecessary, but it does play roles in the immune system, in regulating makeup of gut bacteria, and now this study shows it also plays roles in Parkinson's disease. NutraIngredients reported previously on the theory that gut microbes may trigger Parkinson's disease. Labrie said that the appendix was just one possible place for the disease to start, but there are likely other origin points.

And the appendix, long thought of as pointless in the human body, contained the substance that kills brain cells.

The scientists state that it is the organ where the protein thrives which moves up to the brain.

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